Antibody production using a ciliate generates unusual antibody glycoforms displaying enhanced cell-killing activity

Antibody glycosylation is a key parameter in the optimization of antibody therapeutics. Here, we describe the production of the anti-cancer monoclonal antibody rituximab in the unicellular ciliate, Tetrahymena thermophila. The resulting antibody demonstrated enhanced antibody-dependent cell-mediated...

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Detalles Bibliográficos
Autores principales: Calow, Jenny, Behrens, Anna-Janina, Mader, Sonja, Bockau, Ulrike, Struwe, Weston B., Harvey, David J., Cormann, Kai U., Nowaczyk, Marc M., Loser, Karin, Schinor, Daniel, Hartmann, Marcus W.W., Crispin, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098438/
https://www.ncbi.nlm.nih.gov/pubmed/27594301
http://dx.doi.org/10.1080/19420862.2016.1228504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098438/
https://www.ncbi.nlm.nih.gov/pubmed/27594301
http://dx.doi.org/10.1080/19420862.2016.1228504

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