Oxidation in the complementarity-determining regions differentially influences the properties of therapeutic antibodies

Therapeutic antibodies can undergo a variety of chemical modification reactions in vitro. Depending on the site of modification, either antigen binding or Fc-mediated functions can be affected. Oxidation of tryptophan residues is one of the post-translational modifications leading to altered antibod...

Descripción completa

Detalles Bibliográficos
Autores principales: Dashivets, Tetyana, Stracke, Jan, Dengl, Stefan, Knaupp, Alexander, Pollmann, Jan, Buchner, Johannes, Schlothauer, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098445/
https://www.ncbi.nlm.nih.gov/pubmed/27612038
http://dx.doi.org/10.1080/19420862.2016.1231277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098445/
https://www.ncbi.nlm.nih.gov/pubmed/27612038
http://dx.doi.org/10.1080/19420862.2016.1231277

Ejemplares similares