Cargando…
Oxidation in the complementarity-determining regions differentially influences the properties of therapeutic antibodies
Therapeutic antibodies can undergo a variety of chemical modification reactions in vitro. Depending on the site of modification, either antigen binding or Fc-mediated functions can be affected. Oxidation of tryptophan residues is one of the post-translational modifications leading to altered antibod...
Autores principales: | Dashivets, Tetyana, Stracke, Jan, Dengl, Stefan, Knaupp, Alexander, Pollmann, Jan, Buchner, Johannes, Schlothauer, Tilman |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098445/ https://www.ncbi.nlm.nih.gov/pubmed/27612038 http://dx.doi.org/10.1080/19420862.2016.1231277 |
Ejemplares similares
-
Multi-Angle Effector Function Analysis of Human Monoclonal IgG Glycovariants
por: Dashivets, Tetyana, et al.
Publicado: (2015) -
A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies
por: Stracke, Jan, et al.
Publicado: (2014) -
In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity
por: Thomann, Marco, et al.
Publicado: (2015) -
Antibody complementarity determining region design using high-capacity machine learning
por: Liu, Ge, et al.
Publicado: (2020) -
Improving antibody affinity through in vitro mutagenesis in complementarity determining regions
por: Ye, Wei, et al.
Publicado: (2022)