Charge heterogeneity: Basic antibody charge variants with increased binding to Fc receptors

We identified active isoforms of the chimeric anti-GD2 antibody, ch14.18, a recombinant antibody produced in Chinese hamster ovary cells, which is already used in clinical trials.(1,2,3) We separated the antibody by high resolution ion-exchange chromatography with linear pH gradient elution into aci...

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Detalles Bibliográficos
Autores principales: Hintersteiner, Beate, Lingg, Nico, Zhang, Peiqing, Woen, Susanto, Hoi, Kong Meng, Stranner, Stefan, Wiederkum, Susanne, Mutschlechner, Oliver, Schuster, Manfred, Loibner, Hans, Jungbauer, Alois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098448/
https://www.ncbi.nlm.nih.gov/pubmed/27559765
http://dx.doi.org/10.1080/19420862.2016.1225642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098448/
https://www.ncbi.nlm.nih.gov/pubmed/27559765
http://dx.doi.org/10.1080/19420862.2016.1225642

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