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Charge heterogeneity: Basic antibody charge variants with increased binding to Fc receptors
We identified active isoforms of the chimeric anti-GD2 antibody, ch14.18, a recombinant antibody produced in Chinese hamster ovary cells, which is already used in clinical trials.(1,2,3) We separated the antibody by high resolution ion-exchange chromatography with linear pH gradient elution into aci...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098448/ https://www.ncbi.nlm.nih.gov/pubmed/27559765 http://dx.doi.org/10.1080/19420862.2016.1225642 |