Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo

The T-cell adjuvanticity of mycobacterial cord factor trehalose 6,6'-dimycolate (TDM) is well established. The identification of the C-type lectin Mincle on innate immune cells as the receptor for TDM and its synthetic analogue trehalose 6,6'-dibehenate (TDB) has raised interest in develop...

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Detalles Bibliográficos
Autores principales: Huber, Alexandra, Kallerup, Rie S, Korsholm, Karen S, Franzyk, Henrik, Lepenies, Bernd, Christensen, Dennis, Foged, Camilla, Lang, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098696/
https://www.ncbi.nlm.nih.gov/pubmed/27252171
http://dx.doi.org/10.1177/1753425916651132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098696/
https://www.ncbi.nlm.nih.gov/pubmed/27252171
http://dx.doi.org/10.1177/1753425916651132

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