Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations

The conformation of HIV-1 envelope (Env) glycoprotein trimers is key in ensuring protection against waves of neutralizing antibodies generated during infection, while maintaining sufficient exposure of the CD4 binding site (CD4bs) for viral entry. The CD4 binding loop on Env is an early contact site...

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Detalles Bibliográficos
Autores principales: Duenas-Decamp, Maria, Jiang, Li, Bolon, Daniel, Clapham, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098743/
https://www.ncbi.nlm.nih.gov/pubmed/27820858
http://dx.doi.org/10.1371/journal.ppat.1005988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098743/
https://www.ncbi.nlm.nih.gov/pubmed/27820858
http://dx.doi.org/10.1371/journal.ppat.1005988

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