Fast-to-Slow Transition of Skeletal Muscle Contractile Function and Corresponding Changes in Myosin Heavy and Light Chain Formation in the R6/2 Mouse Model of Huntington’s Disease

Huntington´s disease (HD) is a hereditary neurodegenerative disease resulting from an expanded polyglutamine sequence (poly-Q) in the protein huntingtin (HTT). Various studies report atrophy and metabolic pathology of skeletal muscle in HD and suggest as part of the process a fast-to-slow fiber type...

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Detalles Bibliográficos
Autores principales: Hering, Tanja, Braubach, Peter, Landwehrmeyer, G. Bernhard, Lindenberg, Katrin S., Melzer, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098792/
https://www.ncbi.nlm.nih.gov/pubmed/27820862
http://dx.doi.org/10.1371/journal.pone.0166106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098792/
https://www.ncbi.nlm.nih.gov/pubmed/27820862
http://dx.doi.org/10.1371/journal.pone.0166106

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