ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP Model of Parkinson Disease

Inflammation contributes to the death of dopaminergic neurons in Parkinson disease and can be accompanied by acidification of extracellular pH, which may activate acid-sensing ion channels (ASIC). Accordingly, amiloride, a non-selective inhibitor of ASIC, was protective in an acute 1-methyl-4-phenyl...

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Detalles Bibliográficos
Autores principales: Komnig, Daniel, Imgrund, Silke, Reich, Arno, Gründer, Stefan, Falkenburger, Björn H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098794/
https://www.ncbi.nlm.nih.gov/pubmed/27820820
http://dx.doi.org/10.1371/journal.pone.0165235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098794/
https://www.ncbi.nlm.nih.gov/pubmed/27820820
http://dx.doi.org/10.1371/journal.pone.0165235

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