Cargando…

Imaging the NADH:NAD(+) Homeostasis for Understanding the Metabolic Response of Mycobacterium to Physiologically Relevant Stresses

The NADH:NAD(+) ratio is the primary indicator of the metabolic state of bacteria. NAD(H) homeostasis is critical for Mycobacterium tuberculosis (Mtb) survival and is thus considered an important drug target, but the spatio-temporal measurements of NAD(H) remain a challenge. Genetically encoded fluo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhat, Shabir A., Iqbal, Iram K., Kumar, Ashwani
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099167/ https://www.ncbi.nlm.nih.gov/pubmed/27878107 http://dx.doi.org/10.3389/fcimb.2016.00145

Ejemplares similares

Dysregulated NAD(H) homeostasis associated with ciprofloxacin tolerance in Escherichia coli investigated on a single-cell level with the Peredox [NADH:NAD+] biosensor
por: Urbaniec, Joanna, et al.
Publicado: (2023)

Ectopic Expression of Rv0023 Mediates Isoniazid/Ethionamide Tolerance via Altering NADH/NAD(+) Levels in Mycobacterium smegmatis
por: Gupta, Shailesh Kumar, et al.
Publicado: (2020)

Rapamycin maintains NAD(+)/NADH redox homeostasis in muscle cells
por: Zhang, Zhigang, et al.
Publicado: (2020)

Methotrexate use and NAD(+)/NADH metabolism in psoriatic keratinocytes
por: Liszewska, Agata, et al.
Publicado: (2020)

In Vivo NADH/NAD(+) Biosensing Reveals the Dynamics of Cytosolic Redox Metabolism in Plants
por: Steinbeck, Janina, et al.
Publicado: (2020)

Mitochondrial NAD(+)/NADH Redox State and Diabetic Cardiomyopathy
por: Berthiaume, Jessica M., et al.
Publicado: (2019)

NADH/NAD(+) Redox Imbalance and Diabetic Kidney Disease
por: Yan, Liang-Jun
Publicado: (2021)

Biochemical Issues in Estimation of Cytosolic Free NAD/NADH Ratio
por: Sun, Feifei, et al.
Publicado: (2012)

Protocols for analyzing metabolic derangements caused by increased NADH/NAD(+) ratio in cell lines and in mice
por: Liu, Shanshan, et al.
Publicado: (2022)

Sources and implications of NADH/NAD(+) redox imbalance in diabetes and its complications
por: Wu, Jinzi, et al.
Publicado: (2016)

The mechanism of RNA 5′ capping with NAD(+), NADH, and desphospho-CoA
por: Bird, Jeremy G., et al.
Publicado: (2016)

Tolerance to NADH/NAD(+) imbalance anticipates aging and anti-aging interventions
por: Alonso-Lavin, Alvar J., et al.
Publicado: (2021)

Global Metabolic Shifts in Age and Alzheimer’s Disease Mouse Brains Pivot at NAD(+)/NADH Redox Sites
por: Dong, Yue, et al.
Publicado: (2019)

NAD(+)/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro
por: Yuan, Xuegang, et al.
Publicado: (2020)

Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation
por: Xu, Yuanyuan, et al.
Publicado: (2023)

Evaluation of Antibacterial Activity of Thiourea Derivative TD4 against Methicillin-Resistant Staphylococcus aureus via Destroying the NAD+/NADH Homeostasis
por: Hou, Yachen, et al.
Publicado: (2023)

Cofactor engineering to regulate NAD(+)/NADH ratio with its application to phytosterols biotransformation
por: Su, Liqiu, et al.
Publicado: (2017)

An engineered enzyme that targets circulating lactate to alleviate intracellular NADH/NAD(+) imbalance
por: Patgiri, Anupam, et al.
Publicado: (2020)

Genetically encoded biosensors for evaluating NAD(+)/NADH ratio in cytosolic and mitochondrial compartments
por: Hu, Qingxun, et al.
Publicado: (2021)

Sex-related differences in human plasma NAD(+)/NADH levels depend on age
por: Schwarzmann, Luisa, et al.
Publicado: (2021)

Influence of electrode potential, pH and NAD(+) concentration on the electrochemical NADH regeneration
por: Aamer, Emad, et al.
Publicado: (2022)

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis
por: Sharma, Ritu, et al.
Publicado: (2023)

Overexpression of a Water-Forming NADH Oxidase Improves the Metabolism and Stress Tolerance of Saccharomyces cerevisiae in Aerobic Fermentation
por: Shi, Xinchi, et al.
Publicado: (2016)

Investigation of NADH Binding, Hydride Transfer, and NAD(+) Dissociation during NADH Oxidation by Mitochondrial Complex I Using Modified Nicotinamide Nucleotides
por: Birrell, James A., et al.
Publicado: (2013)

NADH Dehydrogenases in Pseudomonas aeruginosa Growth and Virulence
por: Torres, Angela, et al.
Publicado: (2019)

Syntrophomonas wolfei Uses an NADH-Dependent, Ferredoxin-Independent [FeFe]-Hydrogenase To Reoxidize NADH
por: Losey, Nathaniel A., et al.
Publicado: (2017)

Insights into the inhibitory mechanisms of NADH on the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase
por: Liu, Yabing, et al.
Publicado: (2018)

Toxicity of Melaleuca alternifolia essential oil to the mitochondrion and NAD(+)/NADH dehydrogenase in Tribolium confusum
por: Liao, Min, et al.
Publicado: (2018)

Tracking the Courier: In Planta Imaging of NADH/NAD(+) Ratios with a Genetically Encoded Biosensor
por: Hõrak, Hanna
Publicado: (2020)

In planta study of photosynthesis and photorespiration using NADPH and NADH/NAD(+) fluorescent protein sensors
por: Lim, Shey-Li, et al.
Publicado: (2020)

Neuroprotection in Glaucoma: NAD(+)/NADH Redox State as a Potential Biomarker and Therapeutic Target
por: Petriti, Bledi, et al.
Publicado: (2021)

The effect of succinate on brain NADH/NAD(+) redox state and high energy phosphate metabolism in acute traumatic brain injury
por: Stovell, Matthew G., et al.
Publicado: (2018)

Distribution, Evolution, Catalytic Mechanism, and Physiological Functions of the Flavin-Based Electron-Bifurcating NADH-Dependent Reduced Ferredoxin: NADP(+) Oxidoreductase
por: Liang, Jiyu, et al.
Publicado: (2019)

Synthesis of [4S‐(2)H]NADH, [4R‐(2)H]NADH, [4‐(2)H(2)]NADH and [4‐(2)H]NAD(+) cofactors through heterogeneous biocatalysis in heavy water
por: Rowbotham, Jack S., et al.
Publicado: (2021)

Investigation of the Role That NADH Peroxidase Plays in Oxidative Stress Survival in Group B Streptococcus
por: Korir, Michelle L., et al.
Publicado: (2018)

Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD(+) redox
por: Yang, Liang, et al.
Publicado: (2020)

Assessment of NADH/NAD(+) Redox Imbalance in Psoriatic Lesions Using the FMSF Technique: Therapeutic Aspects
por: Gebicki, Jerzy, et al.
Publicado: (2023)

Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery
por: Iqbal, Iram Khan, et al.
Publicado: (2018)

NAD(+) Homeostasis and NAD(+)-Consuming Enzymes: Implications for Vascular Health
por: Campagna, Roberto, et al.
Publicado: (2023)

Understanding Metabolic Remodeling in Mycobacterium smegmatis to Overcome Energy Exigency and Reductive Stress Under Energy-Compromised State
por: Patil, Varsha, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fgtdrrsj77r0apvmctit82rkbk