Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression

OBJECTIVE: Previous studies suggested that microRNA-21 may be upregulated in the liver in non-alcoholic steatohepatitis (NASH), but its role in the development of this disease remains unknown. This study aimed to determine the role of microRNA-21 in NASH. DESIGN: We inhibited or suppressed microRNA-...

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Detalles Bibliográficos
Autores principales: Loyer, Xavier, Paradis, Valérie, Hénique, Carole, Vion, Anne-Clémence, Colnot, Nathalie, Guerin, Coralie L, Devue, Cécile, On, Sissi, Scetbun, Jérémy, Romain, Mélissa, Paul, Jean-Louis, Rothenberg, Marc E, Marcellin, Patrick, Durand, François, Bedossa, Pierre, Prip-Buus, Carina, Baugé, Eric, Staels, Bart, Boulanger, Chantal M, Tedgui, Alain, Rautou, Pierre-Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Hepatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099209/
https://www.ncbi.nlm.nih.gov/pubmed/26338827
http://dx.doi.org/10.1136/gutjnl-2014-308883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099209/
https://www.ncbi.nlm.nih.gov/pubmed/26338827
http://dx.doi.org/10.1136/gutjnl-2014-308883

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