Edoxaban drug–drug interactions with ketoconazole, erythromycin, and cyclosporine

AIMS: Edoxaban, a novel factor Xa inhibitor, is a substrate of cytochrome P450 3 A4 (CYP3A4) and the efflux transporter P‐glycoprotein (P‐gp). Three edoxaban drug–drug interaction studies examined the effects of P‐gp inhibitors with varying degrees of CYP3A4 inhibition. METHODS: In each study, healt...

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Detalles Bibliográficos
Autores principales: Parasrampuria, Dolly A., Mendell, Jeanne, Shi, Minggao, Matsushima, Nobuko, Zahir, Hamim, Truitt, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Drug Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099547/
https://www.ncbi.nlm.nih.gov/pubmed/27530188
http://dx.doi.org/10.1111/bcp.13092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099547/
https://www.ncbi.nlm.nih.gov/pubmed/27530188
http://dx.doi.org/10.1111/bcp.13092

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