Inhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespan

A unique feature of female germ cell development in mammals is their remarkably long arrest at the prophase of meiosis I, which lasts up to 50 years in humans. Both dormant and growing oocytes are arrested at prophase I and completely lack the ability to resume meiosis. Here, we show that the prolon...

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Detalles Bibliográficos
Autores principales: Adhikari, Deepak, Busayavalasa, Kiran, Zhang, Jingjing, Hu, Mengwen, Risal, Sanjiv, Bayazit, Mustafa Bilal, Singh, Meenakshi, Diril, M Kasim, Kaldis, Philipp, Liu, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099868/
https://www.ncbi.nlm.nih.gov/pubmed/27767095
http://dx.doi.org/10.1038/cr.2016.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099868/
https://www.ncbi.nlm.nih.gov/pubmed/27767095
http://dx.doi.org/10.1038/cr.2016.119

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