Epistasis and Pleiotropy Affect the Modularity of the Genotype–Phenotype Map of Cross-Resistance in HIV-1

The genotype–phenotype (GP) map is a central concept in evolutionary biology as it describes the mapping of molecular genetic variation onto phenotypic trait variation. Our understanding of that mapping remains partial, especially when trying to link functional clustering of pleiotropic gene effects...

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Detalles Bibliográficos
Autores principales: Polster, Robert, Petropoulos, Christos J., Bonhoeffer, Sebastian, Guillaume, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100054/
https://www.ncbi.nlm.nih.gov/pubmed/27678053
http://dx.doi.org/10.1093/molbev/msw206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100054/
https://www.ncbi.nlm.nih.gov/pubmed/27678053
http://dx.doi.org/10.1093/molbev/msw206

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