A positive feedback loop involving the Wnt/β-catenin/MYC/Sox2 axis defines a highly tumorigenic cell subpopulation in ALK-positive anaplastic large cell lymphoma

BACKGROUND: We have previously described the existence of two phenotypically distinct cell subsets in ALK-positive anaplastic large cell lymphoma (ALK + ALCL) based on their differential responsiveness to a Sox2 reporter (SRR2), with reporter-responsive (RR) cells being more tumorigenic and chemores...

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Detalles Bibliográficos
Autores principales: Wu, Chengsheng, Zhang, Hai-Feng, Gupta, Nidhi, Alshareef, Abdulraheem, Wang, Qian, Huang, Yung-Hsing, Lewis, Jamie T., Douglas, Donna N., Kneteman, Norman M., Lai, Raymond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100098/
https://www.ncbi.nlm.nih.gov/pubmed/27821172
http://dx.doi.org/10.1186/s13045-016-0349-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100098/
https://www.ncbi.nlm.nih.gov/pubmed/27821172
http://dx.doi.org/10.1186/s13045-016-0349-z

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