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Autoregressive transitional ordinal model to test for treatment effect in neurological trials with complex endpoints
BACKGROUND: A number of potential therapeutic approaches for neurological disorders have failed to provide convincing evidence of efficacy, prompting pharmaceutical and health companies to discontinue their involvement in drug development. Limitations in the statistical analysis of complex endpoints...
Autores principales: | Tanadini, Lorenzo G., Steeves, John D., Curt, Armin, Hothorn, Torsten |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100172/ https://www.ncbi.nlm.nih.gov/pubmed/27821067 http://dx.doi.org/10.1186/s12874-016-0251-y |
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