A painful TR(i)P to lysosomes

The ion channel TRPA1 detects noxious stimuli at the plasma membrane of neurons and elicits pain and inflammation. In this issue, Shang et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603081) report that TRPA1 also localizes to lysosomal membranes of neurons, releasing intracellular Ca(...

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Detalles Bibliográficos
Autores principales: Gu, Mingxue, Xu, Haoxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100301/
https://www.ncbi.nlm.nih.gov/pubmed/27799365
http://dx.doi.org/10.1083/jcb.201610067
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author Gu, Mingxue
Xu, Haoxing
author_facet Gu, Mingxue
Xu, Haoxing
author_sort Gu, Mingxue
collection PubMed
description The ion channel TRPA1 detects noxious stimuli at the plasma membrane of neurons and elicits pain and inflammation. In this issue, Shang et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603081) report that TRPA1 also localizes to lysosomal membranes of neurons, releasing intracellular Ca(2+) to trigger vesicle exocytosis and neuropeptide release.
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spelling pubmed-51003012017-05-07 A painful TR(i)P to lysosomes Gu, Mingxue Xu, Haoxing J Cell Biol Commentary The ion channel TRPA1 detects noxious stimuli at the plasma membrane of neurons and elicits pain and inflammation. In this issue, Shang et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603081) report that TRPA1 also localizes to lysosomal membranes of neurons, releasing intracellular Ca(2+) to trigger vesicle exocytosis and neuropeptide release. The Rockefeller University Press 2016-11-07 /pmc/articles/PMC5100301/ /pubmed/27799365 http://dx.doi.org/10.1083/jcb.201610067 Text en © 2016 Gu and Xu This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Gu, Mingxue
Xu, Haoxing
A painful TR(i)P to lysosomes
title A painful TR(i)P to lysosomes
title_full A painful TR(i)P to lysosomes
title_fullStr A painful TR(i)P to lysosomes
title_full_unstemmed A painful TR(i)P to lysosomes
title_short A painful TR(i)P to lysosomes
title_sort painful tr(i)p to lysosomes
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100301/
https://www.ncbi.nlm.nih.gov/pubmed/27799365
http://dx.doi.org/10.1083/jcb.201610067
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