Elimination of unaltered DNA in mixed clinical samples via nuclease-assisted minor-allele enrichment

Presence of excess unaltered, wild-type (WT) DNA providing no information of biological or clinical value often masks rare alterations containing diagnostic or therapeutic clues in cancer, prenatal diagnosis, infectious diseases or organ transplantation. With the surge of high-throughput technologie...

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Detalles Bibliográficos
Autores principales: Song, Chen, Liu, Yibin, Fontana, Rachel, Makrigiorgos, Alexander, Mamon, Harvey, Kulke, Matthew H., Makrigiorgos, G. Mike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100565/
https://www.ncbi.nlm.nih.gov/pubmed/27431322
http://dx.doi.org/10.1093/nar/gkw650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100565/
https://www.ncbi.nlm.nih.gov/pubmed/27431322
http://dx.doi.org/10.1093/nar/gkw650

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