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An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting
The CRISPR/Cas9 system is a powerful genome editing tool and has been widely used for biomedical research. However, many challenges, such as off-target effects and lack of easy solutions for multiplex targeting, are still limiting its applications. To overcome these challenges, we first developed a...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100567/ https://www.ncbi.nlm.nih.gov/pubmed/27458201 http://dx.doi.org/10.1093/nar/gkw660 |