Cargando…
Transcription of telomeric DNA leads to high levels of homologous recombination and t-loops
The formation of DNA loops at chromosome ends (t-loops) and the transcription of telomeres producing G-rich RNA (TERRA) represent two central features of telomeres. To explore a possible link between them we employed artificial human telomeres containing long arrays of TTAGGG repeats flanked by the...
Autores principales: | Kar, Anirban, Willcox, Smaranda, Griffith, Jack D. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100571/ https://www.ncbi.nlm.nih.gov/pubmed/27608724 http://dx.doi.org/10.1093/nar/gkw779 |
Ejemplares similares
-
A New View of the T-Loop Junction: Implications for Self-Primed Telomere Extension, Expansion of Disease-Related Nucleotide Repeat Blocks, and Telomere Evolution
por: Tomaska, Lubomir, et al.
Publicado: (2019) -
Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination
por: Basenko, Evelina Y., et al.
Publicado: (2010) -
Flap endonuclease Rad27 cleaves the RNA of R-loop structures to suppress telomere recombination
por: Liu, Chia-Chun, et al.
Publicado: (2023) -
BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage
por: Lu, Huimei, et al.
Publicado: (2007) -
Non-conservative homologous recombination in human B lymphocytes is promoted by activation-induced cytidine deaminase and transcription
por: Mierau, Maren, et al.
Publicado: (2008)