DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions

Binding-induced conformational changes of a protein at regions distant from the binding site may play crucial roles in protein function and regulation. The p53 tumour suppressor is an example of such an allosterically regulated protein. Little is known, however, about how DNA binding can affect dist...

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Detalles Bibliográficos
Autores principales: Lambrughi, Matteo, De Gioia, Luca, Gervasio, Francesco Luigi, Lindorff-Larsen, Kresten, Nussinov, Ruth, Urani, Chiara, Bruschi, Maurizio, Papaleo, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100575/
https://www.ncbi.nlm.nih.gov/pubmed/27604871
http://dx.doi.org/10.1093/nar/gkw770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100575/
https://www.ncbi.nlm.nih.gov/pubmed/27604871
http://dx.doi.org/10.1093/nar/gkw770

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