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DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions
Binding-induced conformational changes of a protein at regions distant from the binding site may play crucial roles in protein function and regulation. The p53 tumour suppressor is an example of such an allosterically regulated protein. Little is known, however, about how DNA binding can affect dist...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100575/ https://www.ncbi.nlm.nih.gov/pubmed/27604871 http://dx.doi.org/10.1093/nar/gkw770 |