SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC

The role of Sirtuin 6 (SIRT6) as a tumor suppressor or oncogene in liver cancer remains controversial. Thus, we identified the specific role of SIRT6 in the progression of hepatocellular carcinoma (HCC). SIRT6 expression was significantly higher in HCC cell lines and HCC tissues from 138 patients th...

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Detalles Bibliográficos
Autores principales: Lee, Namgyu, Ryu, Hye Guk, Kwon, Jung-Hee, Kim, Dae-Kyum, Kim, Sae Rom, Wang, Hee Jung, Kim, Kyong-Tai, Choi, Kwan Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100879/
https://www.ncbi.nlm.nih.gov/pubmed/27824900
http://dx.doi.org/10.1371/journal.pone.0165835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100879/
https://www.ncbi.nlm.nih.gov/pubmed/27824900
http://dx.doi.org/10.1371/journal.pone.0165835

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