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Exploring Flexibility of Progesterone Receptor Ligand Binding Domain Using Molecular Dynamics
Progesterone receptor (PR), a member of nuclear receptor (NR) superfamily, plays a vital role for female reproductive tissue development, differentiation and maintenance. PR ligand, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene re...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100906/ https://www.ncbi.nlm.nih.gov/pubmed/27824891 http://dx.doi.org/10.1371/journal.pone.0165824 |