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Exploring Flexibility of Progesterone Receptor Ligand Binding Domain Using Molecular Dynamics

Progesterone receptor (PR), a member of nuclear receptor (NR) superfamily, plays a vital role for female reproductive tissue development, differentiation and maintenance. PR ligand, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene re...

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Detalles Bibliográficos
Autores principales: Zheng, Liangzhen, Lin, Valerie Chunling, Mu, Yuguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100906/
https://www.ncbi.nlm.nih.gov/pubmed/27824891
http://dx.doi.org/10.1371/journal.pone.0165824