Demethylation of MicroRNA-124a Genes Attenuated Proliferation of Rheumatoid Arthritis Derived Fibroblast-Like Synoviocytes and Synthesis of Tumor Necrosis Factor-α

OBJECTIVE: To examine the impact of 5-Aza-2ʹ-deoxycytidine (5-AzadC) on methylation status of miR-124a genes in rheumatoid arthritis (RA) associated fibroblast-like synoviocytes (FLS) and its effect on RA-FLS proliferation and TNF-α expression. MATERIALS AND METHODS: FLS were isolated from seven RA-...

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Detalles Bibliográficos
Autores principales: Zhou, Qiao, Long, Li, Zhou, Ting, Tian, Juan, Zhou, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100945/
https://www.ncbi.nlm.nih.gov/pubmed/27824863
http://dx.doi.org/10.1371/journal.pone.0164207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100945/
https://www.ncbi.nlm.nih.gov/pubmed/27824863
http://dx.doi.org/10.1371/journal.pone.0164207

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