Domain-swapped T cell receptors improve the safety of TCR gene therapy

T cells engineered to express a tumor-specific αβ T cell receptor (TCR) mediate anti-tumor immunity. However, mispairing of the therapeutic αβ chains with endogenous αβ chains reduces therapeutic TCR surface expression and generates self-reactive TCRs. We report a general strategy to prevent TCR mis...

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Detalles Bibliográficos
Autores principales: Bethune, Michael T, Gee, Marvin H, Bunse, Mario, Lee, Mark S, Gschweng, Eric H, Pagadala, Meghana S, Zhou, Jing, Cheng, Donghui, Heath, James R, Kohn, Donald B, Kuhns, Michael S, Uckert, Wolfgang, Baltimore, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101000/
https://www.ncbi.nlm.nih.gov/pubmed/27823582
http://dx.doi.org/10.7554/eLife.19095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101000/
https://www.ncbi.nlm.nih.gov/pubmed/27823582
http://dx.doi.org/10.7554/eLife.19095

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