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SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism

The fate of secretory and membrane proteins that mislocalize to the cytosol is decided by a collaboration between cochaperone SGTA (small, glutamine-rich, tetratricopeptide repeat protein alpha) and the BAG6 complex, whose operation relies on multiple transient and subtly discriminated interactions...

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Detalles Bibliográficos
Autores principales: Thapaliya, Arjun, Nyathi, Yvonne, Martínez-Lumbreras, Santiago, Krysztofinska, Ewelina M., Evans, Nicola J., Terry, Isabelle L., High, Stephen, Isaacson, Rivka L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101480/
https://www.ncbi.nlm.nih.gov/pubmed/27827410
http://dx.doi.org/10.1038/srep36622