Cargando…

SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism

The fate of secretory and membrane proteins that mislocalize to the cytosol is decided by a collaboration between cochaperone SGTA (small, glutamine-rich, tetratricopeptide repeat protein alpha) and the BAG6 complex, whose operation relies on multiple transient and subtly discriminated interactions...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thapaliya, Arjun, Nyathi, Yvonne, Martínez-Lumbreras, Santiago, Krysztofinska, Ewelina M., Evans, Nicola J., Terry, Isabelle L., High, Stephen, Isaacson, Rivka L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101480/ https://www.ncbi.nlm.nih.gov/pubmed/27827410 http://dx.doi.org/10.1038/srep36622

Ejemplares similares

Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control
por: Martínez-Lumbreras, Santiago, et al.
Publicado: (2018)

Binding of SGTA to Rpn13 selectively modulates protein quality control
por: Leznicki, Pawel, et al.
Publicado: (2015)

Solution Structure of the SGTA Dimerisation Domain and Investigation of Its Interactions with the Ubiquitin-Like Domains of BAG6 and UBL4A
por: Darby, John F., et al.
Publicado: (2014)

The Association of BAG6 with SGTA and Tail-Anchored Proteins
por: Leznicki, Pawel, et al.
Publicado: (2013)

Structural and functional insights into the E3 ligase, RNF126
por: Krysztofinska, Ewelina M., et al.
Publicado: (2016)

Structural and Functional Insights into Small, Glutamine-Rich, Tetratricopeptide Repeat Protein Alpha
por: Roberts, Joanna D., et al.
Publicado: (2015)

Structure and Interactions of the TPR Domain of Sgt2 with Yeast Chaperones and Ybr137wp
por: Krysztofinska, Ewelina M., et al.
Publicado: (2017)

USP5 enhances SGTA mediated protein quality control
por: Hill, Jake, et al.
Publicado: (2022)

The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease
por: Benarroch, Rashi, et al.
Publicado: (2019)

SGTA associates with nascent membrane protein precursors
por: Leznicki, Pawel, et al.
Publicado: (2020)

SGTA regulates the cytosolic quality control of hydrophobic substrates
por: Wunderley, Lydia, et al.
Publicado: (2014)

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12
por: Riedinger, Christiane, et al.
Publicado: (2010)

Polyubiquitin and ubiquitin-like signals share common recognition sites on proteasomal subunit Rpn1
por: Boughton, Andrew J., et al.
Publicado: (2021)

Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation
por: Boehringer, Jonas, et al.
Publicado: (2012)

Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis
por: Hamazaki, Jun, et al.
Publicado: (2015)

Ubiquitin Receptor RPN13 Mediates the Inhibitory Interaction of Diphenyldihaloketones CLEFMA and EF24 With the 26S Proteasome
por: Rao, Geeta, et al.
Publicado: (2018)

A novel recognition site for polyubiquitin and ubiquitin-like signals in an unexpected region of proteasomal subunit Rpn1
por: Boughton, Andrew J., et al.
Publicado: (2021)

Rpn11-mediated ubiquitin processing in an ancestral archaeal ubiquitination system
por: Fuchs, Adrian C. D., et al.
Publicado: (2018)

A High Affinity hRpn2-Derived Peptide That Displaces Human Rpn13 from Proteasome in 293T Cells
por: Lu, Xiuxiu, et al.
Publicado: (2015)

SGTA associates with intracellular aggregates in neurodegenerative diseases
por: Kubota, Shun, et al.
Publicado: (2021)

Yeast Rpn4 Links the Proteasome and DNA Repair via RAD52 Regulation
por: Spasskaya, Daria S., et al.
Publicado: (2020)

An engineered cell line with a hRpn1-attached handle to isolate proteasomes
por: Negi, Hitendra, et al.
Publicado: (2023)

Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets
por: Lu, Xiuxiu, et al.
Publicado: (2017)

SGTA: A New Player in the Molecular Co-Chaperone Game
por: Philp, Lisa K., et al.
Publicado: (2013)

Structural and Functional Insights into Bacillus subtilis Sigma Factor Inhibitor, CsfB
por: Martínez-Lumbreras, Santiago, et al.
Publicado: (2018)

Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosome
por: Yu, Zanlin, et al.
Publicado: (2011)

Regulators of the Proteasome Pathway, Uch37 and Rpn13, Play Distinct Roles in Mouse Development
por: Al-Shami, Amin, et al.
Publicado: (2010)

Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13
por: Liu, Zhu, et al.
Publicado: (2019)

The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance
por: Schmidt, Rolf M, et al.
Publicado: (2019)

The RPN12a proteasome subunit is essential for the multiple hormonal homeostasis controlling the progression of leaf senescence
por: Boussardon, Clément, et al.
Publicado: (2022)

Blockade of ubiquitin receptor Rpn13 in plasmacytoid dendritic cells triggers anti-myeloma immunity
por: Ray, Arghya, et al.
Publicado: (2019)

The proteasome regulator Rpn4 controls antifungal drug tolerance by coupling protein homeostasis with metabolic responses to drug stress
por: Yau, Ka Pui Sharon, et al.
Publicado: (2023)

Inhibition of Proteasomal Degradation of Rpn4 Impairs Nonhomologous End-Joining Repair of DNA Double-Strand Breaks
por: Ju, Donghong, et al.
Publicado: (2010)

Loss of proteasome subunit RPN-12 causes an increased mean lifespan at a higher temperature in C. elegans
por: Fernando, Lourds, et al.
Publicado: (2020)

The ubiquitin proteasome system in neuropathology
por: Lehman, Norman L.
Publicado: (2009)

The recognition of ubiquitinated proteins by the proteasome
por: Grice, Guinevere L., et al.
Publicado: (2016)

The ubiquitin-proteasome pathway in cancer.
por: Spataro, V., et al.
Publicado: (1998)

Integrity of the Saccharomyces cerevisiae Rpn11 Protein Is Critical for Formation of Proteasome Storage Granules (PSG) and Survival in Stationary Phase
por: Saunier, Rémy, et al.
Publicado: (2013)

The Vpu-interacting Protein SGTA Regulates Expression of a Non-glycosylated Tetherin Species
por: Waheed, Abdul A., et al.
Publicado: (2016)

Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10
por: Buel, Gwen R., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4c1iklfhnck0d3b6sdodgfekjt