High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A β-lactamase, PenL

The omega loop in β-lactamases plays a pivotal role in substrate recognition and catalysis, and some mutations in this loop affect the adaptability of the enzymes to new antibiotics. Various mutations, including substitutions, deletions, and intragenic duplications resulting in tandem repeats (TRs),...

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Detalles Bibliográficos
Autores principales: Yi, Hyojeong, Choi, Jin Myung, Hwang, Junghyun, Prati, Fabio, Cao, Thinh-Phat, Lee, Sung Haeng, Kim, Heenam Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101513/
https://www.ncbi.nlm.nih.gov/pubmed/27827433
http://dx.doi.org/10.1038/srep36527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101513/
https://www.ncbi.nlm.nih.gov/pubmed/27827433
http://dx.doi.org/10.1038/srep36527

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