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High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A β-lactamase, PenL
The omega loop in β-lactamases plays a pivotal role in substrate recognition and catalysis, and some mutations in this loop affect the adaptability of the enzymes to new antibiotics. Various mutations, including substitutions, deletions, and intragenic duplications resulting in tandem repeats (TRs),...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101513/ https://www.ncbi.nlm.nih.gov/pubmed/27827433 http://dx.doi.org/10.1038/srep36527 |