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Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope–Fab complexes

Herein, multiple crystal structures of meditope peptide derivatives incorporating natural and unnatural amino acids bound to the cetuximab Fab domain are presented. The affinity of each derivative was determined by surface plasmon resonance and correlated to the atomic structure. Overall, it was obs...

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Detalles Bibliográficos
Autores principales: Bzymek, Krzysztof P., Avery, Kendra A., Ma, Yuelong, Horne, David A., Williams, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101583/
https://www.ncbi.nlm.nih.gov/pubmed/27834791
http://dx.doi.org/10.1107/S2053230X16016149