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Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope–Fab complexes
Herein, multiple crystal structures of meditope peptide derivatives incorporating natural and unnatural amino acids bound to the cetuximab Fab domain are presented. The affinity of each derivative was determined by surface plasmon resonance and correlated to the atomic structure. Overall, it was obs...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101583/ https://www.ncbi.nlm.nih.gov/pubmed/27834791 http://dx.doi.org/10.1107/S2053230X16016149 |