Resurrecting ancestral structural dynamics of an antiviral immune receptor: adaptive binding pocket reorganization repeatedly shifts RNA preference

BACKGROUND: Although resurrecting ancestral proteins is a powerful tool for understanding the molecular-functional evolution of gene families, nearly all studies have examined proteins functioning in relatively stable biological processes. The extent to which more dynamic systems obey the same ‘rule...

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Detalles Bibliográficos
Autores principales: Pugh, Charles, Kolaczkowski, Oralia, Manny, Austin, Korithoski, Bryan, Kolaczkowski, Bryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101713/
https://www.ncbi.nlm.nih.gov/pubmed/27825296
http://dx.doi.org/10.1186/s12862-016-0818-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101713/
https://www.ncbi.nlm.nih.gov/pubmed/27825296
http://dx.doi.org/10.1186/s12862-016-0818-6

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