The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation

In eukaryotes, many proteins function in multi-subunit complexes that require proper assembly. To maintain complex stoichiometry, cells use the endoplasmic reticulum-associated degradation system to degrade unassembled membrane subunits, but how unassembled soluble proteins are eliminated is undefin...

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Detalles Bibliográficos
Autores principales: Xu, Yue, Anderson, D Eric, Ye, Yihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102030/
https://www.ncbi.nlm.nih.gov/pubmed/27867533
http://dx.doi.org/10.1038/celldisc.2016.40

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102030/
https://www.ncbi.nlm.nih.gov/pubmed/27867533
http://dx.doi.org/10.1038/celldisc.2016.40

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