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The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation
In eukaryotes, many proteins function in multi-subunit complexes that require proper assembly. To maintain complex stoichiometry, cells use the endoplasmic reticulum-associated degradation system to degrade unassembled membrane subunits, but how unassembled soluble proteins are eliminated is undefin...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102030/ https://www.ncbi.nlm.nih.gov/pubmed/27867533 http://dx.doi.org/10.1038/celldisc.2016.40 |