Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cells

Gene therapy for HIV-1 infection is a promising alternative to lifelong combination antiviral drug treatment. Chemokine receptor 5 (CCR5) is the coreceptor required for R5-tropic HIV-1 infection of human cells. Deletion of CCR5 renders cells resistant to R5-tropic HIV-1 infection, and the potential...

Descripción completa

Detalles Bibliográficos
Autores principales: DiGiusto, David L, Cannon, Paula M, Holmes, Michael C, Li, Lijing, Rao, Anitha, Wang, Jianbin, Lee, Gary, Gregory, Philip D., Kim, Kenneth A, Hayward, Samuel B, Meyer, Kathleen, Exline, Colin, Lopez, Evan, Henley, Jill, Gonzalez, Nancy, Bedell, Victoria, Stan, Rodica, Zaia, John A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102145/
https://www.ncbi.nlm.nih.gov/pubmed/27900346
http://dx.doi.org/10.1038/mtm.2016.67

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102145/
https://www.ncbi.nlm.nih.gov/pubmed/27900346
http://dx.doi.org/10.1038/mtm.2016.67

Ejemplares similares