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Prion-Associated Toxicity is Rescued by Elimination of Cotranslational Chaperones
The nascent polypeptide-associated complex (NAC) is a highly conserved but poorly characterized triad of proteins that bind near the ribosome exit tunnel. The NAC is the first cotranslational factor to bind to polypeptides and assist with their proper folding. Surprisingly, we found that deletion of...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102407/ https://www.ncbi.nlm.nih.gov/pubmed/27828954 http://dx.doi.org/10.1371/journal.pgen.1006431 |