Characterization of activating mutations of NOTCH3 in T cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies

Notch receptors have been implicated as oncogenic drivers in several cancers, the most notable example being NOTCH1 in T-cell acute lymphoblastic leukemia (T-ALL). To characterize the role of activated NOTCH3 in cancer, we generated an antibody that detects the neo-epitope created upon gamma-secreta...

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Detalles Bibliográficos
Autores principales: Bernasconi-Elias, Paula, Hu, Tiancen, Jenkins, David, Firestone, Brant, Gans, Sara, Kurth, Esther, Capodieci, Paola, Deplazes-Lauber, Joelle, Petropoulos, Konstantin, Thiel, Phillip, Ponsel, Dirk, Choi, Sung Hee, LeMotte, Peter, London, Anne, Goetcshkes, Margaret, Nolin, Erin, Jones, Michael D., Slocum, Kelly, Kluk, Michael J., Weinstock, David M., Christodoulou, Alexandra, Weinberg, Olga, Jaehrling, Jan, Ettenberg, Seth A., Buckler, Alan, Blacklow, Stephen C., Aster, Jon C., Fryer, Christy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102827/
https://www.ncbi.nlm.nih.gov/pubmed/27157619
http://dx.doi.org/10.1038/onc.2016.133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102827/
https://www.ncbi.nlm.nih.gov/pubmed/27157619
http://dx.doi.org/10.1038/onc.2016.133

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