Contribution of sleep to the repair of neuronal DNA double-strand breaks: evidence from flies and mice

Exploration of a novel environment leads to neuronal DNA double-strand breaks (DSBs). These DSBs are generated by type 2 topoisomerase to relieve topological constrains that limit transcription of plasticity-related immediate early genes. If not promptly repaired, however, DSBs may lead to cell deat...

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Detalles Bibliográficos
Autores principales: Bellesi, Michele, Bushey, Daniel, Chini, Mattia, Tononi, Giulio, Cirelli, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103291/
https://www.ncbi.nlm.nih.gov/pubmed/27830758
http://dx.doi.org/10.1038/srep36804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103291/
https://www.ncbi.nlm.nih.gov/pubmed/27830758
http://dx.doi.org/10.1038/srep36804

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