Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors that dictate the shift between these 2 opposite outcomes remain largely unknown. In this work, we used Δ(9)-tetrahydrocannabinol (THC, the main active component of marijuana, a co...

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Detalles Bibliográficos
Autores principales: Hernández-Tiedra, Sonia, Fabriàs, Gemma, Dávila, David, Salanueva, Íñigo J., Casas, Josefina, Montes, L. Ruth, Antón, Zuriñe, García-Taboada, Elena, Salazar-Roa, María, Lorente, Mar, Nylandsted, Jesper, Armstrong, Jane, López-Valero, Israel, McKee, Christopher S., Serrano-Puebla, Ana, García-López, Roberto, González-Martínez, José, Abad, José L., Hanada, Kentaro, Boya, Patricia, Goñi, Félix, Guzmán, Manuel, Lovat, Penny, Jäättelä, Marja, Alonso, Alicia, Velasco, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Translational Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103338/
https://www.ncbi.nlm.nih.gov/pubmed/27635674
http://dx.doi.org/10.1080/15548627.2016.1213927

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