Elucidation of the glycosylation steps during biosynthesis of antitumor macrolides PM100117 and PM100118 and engineering for novel derivatives

BACKGROUND: Antitumor compounds PM100117 and PM100118 are glycosylated polyketides derived from the marine actinobacteria Streptomyces caniferus GUA-06-05-006A. The organization and characterization of the PM100117/18 biosynthesis gene cluster has been recently reported. RESULTS: Based on the preced...

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Detalles Bibliográficos
Autores principales: Salcedo, Raúl García, Olano, Carlos, Fernández, Rogelio, Braña, Alfredo F., Méndez, Carmen, de la Calle, Fernando, Salas, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103430/
https://www.ncbi.nlm.nih.gov/pubmed/27829451
http://dx.doi.org/10.1186/s12934-016-0591-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103430/
https://www.ncbi.nlm.nih.gov/pubmed/27829451
http://dx.doi.org/10.1186/s12934-016-0591-7

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