Comparative Binding Analysis of Dipeptidyl Peptidase IV (DPP-4) with Antidiabetic Drugs – An Ab Initio Fragment Molecular Orbital Study

Dipeptidyl peptidase IV (DPP-4) enzyme is responsible for the degradation of incretins that stimulates insulin secretion and hence inhibition of DPP-4 becomes an established approach for the treatment of type 2 diabetics. We studied the interaction between DPP-4 and its inhibitor drugs (sitagliptin...

Descripción completa

Detalles Bibliográficos
Autores principales: Arulmozhiraja, Sundaram, Matsuo, Naoya, Ishitsubo, Erika, Okazaki, Seiji, Shimano, Hitoshi, Tokiwa, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104442/
https://www.ncbi.nlm.nih.gov/pubmed/27832184
http://dx.doi.org/10.1371/journal.pone.0166275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104442/
https://www.ncbi.nlm.nih.gov/pubmed/27832184
http://dx.doi.org/10.1371/journal.pone.0166275

Ejemplares similares