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Comparative Binding Analysis of Dipeptidyl Peptidase IV (DPP-4) with Antidiabetic Drugs – An Ab Initio Fragment Molecular Orbital Study

Dipeptidyl peptidase IV (DPP-4) enzyme is responsible for the degradation of incretins that stimulates insulin secretion and hence inhibition of DPP-4 becomes an established approach for the treatment of type 2 diabetics. We studied the interaction between DPP-4 and its inhibitor drugs (sitagliptin...

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Detalles Bibliográficos
Autores principales:	Arulmozhiraja, Sundaram, Matsuo, Naoya, Ishitsubo, Erika, Okazaki, Seiji, Shimano, Hitoshi, Tokiwa, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104442/ https://www.ncbi.nlm.nih.gov/pubmed/27832184 http://dx.doi.org/10.1371/journal.pone.0166275

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