Genetic enhancement of microsomal epoxide hydrolase improves metabolic detoxification but impairs cerebral blood flow regulation

Microsomal epoxide hydrolase (mEH) is a detoxifying enzyme for xenobiotic compounds. Enzymatic activity of mEH can be greatly increased by a point mutation, leading to an E404D amino acid exchange in its catalytic triad. Surprisingly, this variant is not found in any vertebrate species, despite the...

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Detalles Bibliográficos
Autores principales: Marowsky, Anne, Haenel, Karen, Bockamp, Ernesto, Heck, Rosario, Rutishauser, Sibylle, Mule, Nandkishor, Kindler, Diana, Rudin, Markus, Arand, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104800/
https://www.ncbi.nlm.nih.gov/pubmed/26838043
http://dx.doi.org/10.1007/s00204-016-1666-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104800/
https://www.ncbi.nlm.nih.gov/pubmed/26838043
http://dx.doi.org/10.1007/s00204-016-1666-2

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