Soluble γc cytokine receptor suppresses IL-15 signaling and impairs iNKT cell development in the thymus

The soluble γc protein (sγc) is a naturally occurring splice isoform of the γc cytokine receptor that is produced by activated T cells and inhibits γc cytokine signaling. Here we show that sγc expression is also highly upregulated in immature CD4(+)CD8(+) thymocytes but then downregulated in mature...

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Detalles Bibliográficos
Autores principales: Park, Joo-Young, Jo, Yuna, Ko, Eunhee, Luckey, Megan A., Park, Yoo Kyoung, Park, Se-Ho, Park, Jung-Hyun, Hong, Changwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105068/
https://www.ncbi.nlm.nih.gov/pubmed/27833166
http://dx.doi.org/10.1038/srep36962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105068/
https://www.ncbi.nlm.nih.gov/pubmed/27833166
http://dx.doi.org/10.1038/srep36962

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