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Soluble γc cytokine receptor suppresses IL-15 signaling and impairs iNKT cell development in the thymus
The soluble γc protein (sγc) is a naturally occurring splice isoform of the γc cytokine receptor that is produced by activated T cells and inhibits γc cytokine signaling. Here we show that sγc expression is also highly upregulated in immature CD4(+)CD8(+) thymocytes but then downregulated in mature...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105068/ https://www.ncbi.nlm.nih.gov/pubmed/27833166 http://dx.doi.org/10.1038/srep36962 |