Re-visiting the Protamine-2 locus: deletion, but not haploinsufficiency, renders male mice infertile

Protamines are arginine-rich DNA-binding proteins that replace histones in elongating spermatids. This leads to hypercondensation of chromatin and ensures physiological sperm morphology, thereby protecting DNA integrity. In mice and humans, two protamines, protamine-1 (Prm1) and protamine-2 (Prm2) a...

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Detalles Bibliográficos
Autores principales: Schneider, Simon, Balbach, Melanie, Jan F. Jikeli, J F J, Fietz, Daniela, Nettersheim, Daniel, Jostes, Sina, Schmidt, Rovenna, Kressin, Monika, Bergmann, Martin, Wachten, Dagmar, Steger, Klaus, Schorle, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105070/
https://www.ncbi.nlm.nih.gov/pubmed/27833122
http://dx.doi.org/10.1038/srep36764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105070/
https://www.ncbi.nlm.nih.gov/pubmed/27833122
http://dx.doi.org/10.1038/srep36764

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