BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization

BMI1 is a core component of the polycomb repressive complex 1 (PRC1) and emerging data support a role of BMI1 in cancer. The central domain of BMI1 is involved in protein–protein interactions and is essential for its oncogenic activity. Here, we present the structure of BMI1 bound to the polyhomeoti...

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Detalles Bibliográficos
Autores principales: Gray, Felicia, Cho, Hyo Je, Shukla, Shirish, He, Shihan, Harris, Ashley, Boytsov, Bohdan, Jaremko, Łukasz, Jaremko, Mariusz, Demeler, Borries, Lawlor, Elizabeth R., Grembecka, Jolanta, Cierpicki, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105191/
https://www.ncbi.nlm.nih.gov/pubmed/27827373
http://dx.doi.org/10.1038/ncomms13343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105191/
https://www.ncbi.nlm.nih.gov/pubmed/27827373
http://dx.doi.org/10.1038/ncomms13343

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