Antisense Oligonucleotides Modulating Activation of a Nonsense-Mediated RNA Decay Switch Exon in the ATM Gene

ATM (ataxia-telangiectasia, mutated) is an important cancer susceptibility gene that encodes a key apical kinase in the DNA damage response pathway. ATM mutations in the germ line result in ataxia-telangiectasia (A-T), a rare genetic syndrome associated with hypersensitivity to double-strand DNA bre...

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Detalles Bibliográficos
Autores principales: Kralovicova, Jana, Moreno, Pedro M.D., Cross, Nicholas C.P., Pêgo, Ana Paula, Vorechovsky, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105335/
https://www.ncbi.nlm.nih.gov/pubmed/27658045
http://dx.doi.org/10.1089/nat.2016.0635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105335/
https://www.ncbi.nlm.nih.gov/pubmed/27658045
http://dx.doi.org/10.1089/nat.2016.0635

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