Combined Changes in Chloride Regulation and Neuronal Excitability Enable Primary Afferent Depolarization to Elicit Spiking without Compromising its Inhibitory Effects

The central terminals of primary afferent fibers experience depolarization upon activation of GABA(A) receptors (GABA(A)R) because their intracellular chloride concentration is maintained above electrochemical equilibrium. Primary afferent depolarization (PAD) normally mediates inhibition via sodium...

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Detalles Bibliográficos
Autores principales: Takkala, Petri, Zhu, Yi, Prescott, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105942/
https://www.ncbi.nlm.nih.gov/pubmed/27835641
http://dx.doi.org/10.1371/journal.pcbi.1005215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105942/
https://www.ncbi.nlm.nih.gov/pubmed/27835641
http://dx.doi.org/10.1371/journal.pcbi.1005215

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